Along something of the same lines as Nietzche Family Circus, here’s Garfield Minus Garfield — a comic strip obtained by taking an ordinary Garfield strip and airbrushing Garfield the cat completely out of it. Or, as the site itself describes it:
Who would have guessed that when you remove Garfield from the Garfield comic strips, the result is an even better comic about schizophrenia, bipolar disorder, and the empty desperation of modern life? Friends, meet Jon Arbuckle. Let’s laugh and learn with him on a journey deep into the tortured mind of an isolated young everyman as he fights a losing battle against loneliness in a quiet American suburb.
I have to admit, that’s pretty brilliant stuff. Jim Davis likes it too.
[h/t incarnatus est]